LSD: Insight or Insanity?, 1968

From the NIH. A post by Professor Erika Dyck on the history of LSD.

Circulating Now from NLM

Circulating Now welcomes guest blogger Erika Dyck, PhD, Professor and Canada Research Chair in the History of Medicine at the University of Saskatchewan. Today, Dr. Dyck shares some insights on a recently digitized film in the Library’s collection highlighted in our Medical Movies on the Web project.

For Rebels, it’s a Kick…

It’s the late 1960s. Teenagers, a hip voice clues us in, are always looking for kicks, and today’s teens express themselves with cool fashions, groovy hairstyles, and kooky pranks. Not so long ago, our narrator played the character of “Plato,” a troubled teenager, in the 1955 classic Rebel Without a Cause. In that film, Plato idolizes the reckless machismo of young Jim Stark (played by James Dean). In an epic display of bravado, Jim and another boy play a game of “chickie run” in which they drive their cars in parallel directly toward a cliff. Jim leaps…

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Radical Librarians Unite!

Radicalism at the library is about more than just speaking loudly!

Earlier this month I had the opportunity to get involved with a Radical Collections conference at the University of London. It was called “Radical Voices.” In the “post-truth,” “fake news,” “24-hour news cycle” epoch, it’s absolutely vital to examine the way information – all the materials in archives and libraries – are administered. Librarians and archivists control the data, and so their opinions, their political beliefs matter. Big time. The funders of libraries and archives (and special collections therein) matter. Big time. Ultimately, these individuals and organizations are the gatekeepers, determine access to and consumption of information, and help knowledge-creation.

 

Here’s a retrospective from James Hobbs.

“Radicalism and the drive for change can take on many forms in the world of libraries and archives, and the packed room for the Radical Collections: Radicalism and Libraries and Archives conference, which took place at the Institute of Historical Research at Senate House Library on 3 March, heard arguments that covered some ground.

Across four panels, the themes tackled included how collections are being developed, catalogued and organised, and who works in them and uses them. These were interspersed with not one, but two fire alarms to keep us on our toes, which led to impromptu networking sessions on the street outside, resumed at the end of the day with wine and nibbles in the Institute of Historical Research common room.

Starting out, Wendy Russell from the British Film Institute archive explored the barriers faced by the director Ken Loach in the 1980s when his TV series for the new Channel 4 about trade unionism, Questions of Leadership, was commissioned and then scrapped, and considered the archive’s significance beyond the fields of TV and film. Lisa Redlinski and John Wrighton of the University of Brighton spoke about the remit of HE libraries with particular relation to the library’s digitisation of Brighton’s rich history of underground and alternative press. And historian Lucas Richert (University of Strathclyde), in his paper about radical psychiatry, LSD and MDMA, raised issues (among others) about how funding from private and public sources can affect the consumption and “selling” of archives.

Panel 1: Chair Richard Espley, Lucas Richert, Lisa Redlinski, John Wrighton and Wendy Russell

After a lunch interrupted by the fire alarm, Mairéad Mooney (University College Cork) looked at British imperialist influences on libraries in the early days of the Irish Free State, and Amy Todman (National Library of Scotland) spoke about the archiving of Engender, the Scottish feminist organisation, since the 1990s. Siobhan Britton (University of Brighton) explored issues surrounding the collection, preservation and accessibility of zines in libraries. (My thanks to her about a lightbulb moment I had midway through her talk when I had an idea regarding my own dissertation.)

Tamsin Bookey (Tower Hamlets Local History Library and Archives), who navigated the rude interruption mid-presentation by the second fire alarm, described moves in Tower Hamlets to widen participation and attract hard-to-reach potential users (respect people who are hostile, use marketing, get non-gender specific toilets). Katherine Quinn (University of Warwick) spoke about the challenge of radical librarianship in the HE context (the audit culture, and how LIS is drawing on management culture), and, finally, Kirsty Fife (National Media Museum) and Hannah Henthorn (University of Dundee) described the issues they, as marginalised people, faced as they negotiated their way into the archive sector and how the expense of qualifications restrict diversification.

Just how radical some of the ideas discussed really are is debatable. In a point raised by our own Thomas Ash, the non-discriminatory nature of classification terminology, for instance, is evolutionary rather than revolutionary. It’s simply how things should be. A theme running through the day, it seems to me, was that obstacles put in the way of opening up access and information to all – and that really does mean people who currently wouldn’t dream of setting foot in a library or archive – need dismantling, and that means they won’t be the quiet, safe places they are generally perceived to be now. White western patriarchy has had its day. That change seems more sensible and representative of the UK as it is than radical. But the conference provided a great variety of voices that asked questions and offered solutions that deserve deeper and longer consideration – and action.

Julio Cazzasa talked about the problems faced by the Senate House Library’s collection (the Heisler collection of 50,000 items tracing labour and progressive political movements, for instance, is a mixed library and archive collection). Alycia Sellie (CUNY) raised questions of the whiteness of librarians and how collection practices should strive to be radical in relation to the Wisconsin Historical Society’s newspaper and periodicals collection. And the discriminative nature of library classifications (it took the Library of Congress 18 years to remove the subject heading “yellow peril”) and the need for a focus on critical theory in LIS studies were just some of the issues picked up by Gregory Toth of the Senate House Library.”

**

I’m glad that Hobbs chronicled the event so well.

Thanks to all the organizers (Jordan Landes, Richard Espley, and so many others) for giving me a chance to speak about my research on radical psychiatry and MDMA. And if you want a play-by-play from the event, vist this excellent -tweet based – overview of the conference at Storify at https://storify.com/onslies/radical-voices

 

Twin Addictions? Zombies (i.e., The Walking Dead) and Bath Salts

In 2015, we are grappling with the addictive properties of The Walking Dead. Based on the best-selling comic book and developed for TV by Frank Darabont, the series has proven to be as enduring and enslaving as many popular drugs.

walking-dead

With only a month left in Season 6, many questions surround the future of Rick, Daryl, and the rest. The zombie hordes have broken through the wall. Ron has set his sights on Carl and the next episode, which is called “Start to Finish,” will likely see the end of a character. But who will it be? Who’s going to lose a body part or two? Tune in…

But zombies don’t only frequent the big and small screen. They don’t simply occupy pages of novels and graphic novels. Quite the opposite. In recent years, drug addicts on bath salts have been portrayed as nightmarish zombies tearing at the flesh of unwitting victims. Let me explain.

bath salts

Bath salts are examples of new classes of designer drugs, which are sometimes referred to as “legal highs.” These are substances with psychotropic effects that have been or are marketed and distributed for recreational use by exploiting gaps in existing drug legislation. Another popular example is the synthetic cannabinoids (“fake marijuana”) marketed under names such as Spice.

In 2012, the Americans made bath salts illegal through the Synthetic Drug Abuse Prevention Act and then with the Synthetic Cathinones Control Act a year later. At roughly the same time, Canada introduced measures to ban the key ingredient in bath salts, methlyenedioxypyrovalerone (MDPV).

The move to schedule and control the drug was surely warranted, yet one can easily detect how the drug was sensationalized as part of this process. Lurid and grotesque stories were reported about bath salts, including the naked zombie attacker who was shot by police in Miami while biting a victim’s face. Rudy Eugene, the face-chewing “zombie,” wasn’t on any bath salts, contrary to a majority of the stories.

Yet, the nation went into full-on moral panic mode. From PBS and Spin to Forbes and GQ magazine, the public was exposed to the new menace in American society. It was the stuff of nightmares. It was a Zombie Bath Salt Apocalypse.

The Big Picture

Cathinones are naturally occurring amphetamine-like substances that come from Khat, a plant found in eastern Africa which has been chewed since at least the tenth century. Synthetic cathinones, not surprisingly, are lab-created derivatives of this compound, dating back to 1928 or so.

By the 1990s, the use/misuse of the synthetic cathinones began to pop up on radar screens and became an issue with law enforcement and government officials.

Before the recent regulation in the past few years, the designer “bath salts” were purchased from dealers, through online distributors, or at book stores, gas stations, and head shops. They got the nickname because they resembled the everyday Epsom salts that bath-lovers pour in their water when they take a soothing soak.

But there are trade names as well: “Ivory Wave,” “Purple Wave,” “Ocean Burst,” “Monkey Dust,” “Sextacy,” “Vanilla Sky,” and “White Lightning” are just some of the varieties one can put in the body rather than the bathtub. Tough to detect, they can be snorted, smoked, or injected.

And the effects of these are similar to MDMA. Users have reported increased energy and empathy, more sociability, and mental and sexual stimulation. The negative side effects of bath salts, on the other hand, have included difficulty breathing, fatigue, insomnia, muscle twitching, nausea, paranoia, violent behavior, and tachychardia.

A Vicious Circle

Compared to traditional psychotropic drugs (cocaine and LSD, for instance), there is relatively scant medical information available. That has not prevented its assignment to the category of Schedule I, meaning it has no known and accepted medical use.

Yet certain researchers raise interesting points. One is that classifying bath salts as schedule I substances without pre-clinical or human research is very problematic.

This move restricts the number of laboratories and institutions with licenses to study the bath salts. As a result, finding an accepted medical use becomes even more difficult, even though there have been suggestions that bath salts could be a viable alternative to amphetamines in dealing with Attention Deficit Hyperactivity Disorder (ADHD) or severe, treatment-resistant Depression.

This is, in short, a case of the snake eating its tail, and one does not have to look any further than LSD to detect some historical parallels. In the late 1960s, the recreational abuse of LSD as well as the anti-authority, counter-cultural, and outright malevolent images associated with it helped to scuttle research. Now, after over forty years, LSD has begun to make a slow return, and perhaps even a comeback.

lsd

Hyperbole and inaccurate information played a role in the scheduling and controlling of LSD, in other words. This was also the case when it was reported that crazed Mexicans who smoked marijuana went on vicious rampages, or when it was reported that Chinese workers were raping white women in opium dens while customers were “Chasing the Dragon.” With bath salts, which are the latest in a long line of drugs used for their euphoric effects, this hyperbole was readily apparent.

No, bath salts will not turn you into a cannibalistic criminal like Rudy Eugene in Miami. And, no, bath salts will not give you super strength. But the media had no problems in pushing such narratives on news consumers.

Should we be surprised about this type of journalism? Or that it dovetailed with the first synthetic cathinone legislation in 2012, which was passed the same month as the attack? Far from. If anything, the history of drug policy demonstrates how predictable this is.

In the future, the best way to avoid cowering in bed (or hiding behind a big wall) in the face of an imminent zombie bath salt apocalypse is with candor. It’s probably best not to cut off avenues of research or focus on gory thoughts about face-chewing.

the-walking-dead

And, at the very least, it would be prudent to recognize the challenges and dangers of designer drugs like bath salts, even as we place them in a longer history of drugs. This way, like Rick and Daryl, we can create a proactive strategy for evading the zombie hordes.

SMOKE AND MIRRORS – MORE ON VAPING

Last year I had opinion-editorials published in the Saskatoon Star Phoenix and elsewhere. Both focused on “vaping,” Oxford English Dictionary’s word of 2014.

My take was this: we need to think more clearly about e-cigarettes in Saskatoon – as well as the wider world. The government needs to get proactive. We, as consumers, should also think about them more critically. Essentially, we need to cut through all the smoke and mirrors.

300px-Humphrey_Bogart_by_Karsh_(Library_and_Archives_Canada) imagesarticle-1316595870295-0E038E5700000578-348441_466x436

Now, Saskatoon’s city council is voting (that is, tonight folks) on “a vaping ban” in the city.

As reported by the local paper, “If city council approves a proposed change to the local smoking bylaw, use of electronic cigarettes — also known as vaping — will be banned anywhere in Saskatoon that regular cigarettes are. The change, which will be considered at Monday’s council meeting, would expand the city’s Smoking Control Bylaw to include vaping as of Jan. 1, 2016. It would make vaping prohibited in public buildings, bus shelters, schools, businesses and other places cigarettes are currently not allowed.”

So, big changes are afoot here. And these changes could influence the smoking of traditional cigarettes at the local and provincial level. Indeed, many supporters of e-cigs make the case that the new technology deters relapses.

The Star Phoenix also quotes a local “vaping” business owner, Jim Wollf, who said he understands the argument that vaping puts unnatural chemicals into a person’s body, but argued it should be looked at as a harm-reduction strategy.

This is exactly the problem that my opinion-editorials have tackled. Here’s a taster:

“In September 2014, federal Health Minister Rona Ambrose called for more research on e-cigarettes from the Commons standing committee on health. Last month, the committee released its initial report, which called for an end to the legal grey zone that surrounds the technology in Canada and the implementation of a new set of rules that balances the benefits and risks of “vaping.”

Premier Brad Wall and the Saskatchewan government would be wise to take the committee’s advice and do the same. In their brief history, e-cigarettes have proven to be divisive products. They have raised serious challenges for consumers, politicians and health officials. It is time, however, to cut through the fog and for the provincial government to get proactive.”

 

The Canadian Election and Sask Marijuana

The federal election is going to have a profound impact on Saskatchewan’s marijuana industry. So writes D.C. Fraser in a new article for the Regina Leader-Post.

I told Fraser during an interview for the story that “Depending on what the winner suggests about medical marijuana legislation, (it will have) a direct impact on the economy, and on this sector of the economy…”

In many ways, SK has the potential for tremendous growth in the realm of medical marijuana and I’m genuinely intrigued to see what happens in the next few years.

A link to the full Leader-Post article is here.

Dried Buds
Dried Buds

Happy Halloween, and a Freaky Fen-Phen Article

heart foundationskull-taking-drug-opiate-addictionCRI_172252

Happy Halloween, everybody!

The best part of the day is not the cute kids in their adorable costumes. Or the wild parties. Or seeing Michael Jackson’s Thriller over and over and over again. No. The best part has to be the treats.

As I was casually munching chocolate bars with my coffee this morning (Wunderbar is my favourite, hands down!), I thought about the implications. For many Canadians and Americans, cleanses are the answer. Some hit the gym, while others get more drastic and take all sorts of diet pills. Often, it is buying the hot new diet pill, like Time magazine shouts below.

Fen-Phen was one of the hottest diet drugs of the 1990s; unfortunately, it proved dreadfully unsafe. In the Encyclopedia of Pharmacology of Society, I offer a short overview of this weight loss therapy. I recount some of the more ghoulish aspects of the drug. I provide insight into the macabre nature of diet pills, much as I did with another frightening article called Trimming Down.

sage coverfenphencover

This textbook, which is about 2000 pages, will be a fantastic resource for all those people wondering about the role of drugs – including diet drugs – in everyday life. Honestly, the price of the book is blood-curdling, but it’s certainly worth the chills. It answers some crucial questions: How powerful is the drug modern industry? What’s it’s role in society, and how are we influenced by it? Who are the major players? And what does the future of drugs hold?

So, have a great Happy Halloween. Enjoy the candy and costumes. Me, I’m going to probably dole out some treats and watch the Princess Bride, as per household tradition. Remember, a book of Pharmacology and Society’s girth would be a great tool to take out all manner of goblins, ghouls, or rodents of unusual size (ROUS)!

Cheers! Enjoy your treats.

 

LSD Has Wondrous Potential

The return of LSD? Call it a comeback? Maybe, maybe not.

Has LSD Matured?
The Return of Psychedelic R&D
By Lucas Richert and Erika Dyck

In February 2014, Scientific American surprised readers with an editorial that called for an end to the ban on psychedelic drug research and criticized drug regulators for limiting access to such psychedelic drugs as LSD (Lysergic acid-diethylamide), ecstasy (MDMA), and psilocybin.

A few months later, Science further described how scientists are rediscovering these drugs as legitimate treatments as well as tools of investigation. “More and more researchers are turning back to psychedelics” to treat depression, obsessive-compulsive disorder, various addictions, and other categories of mental illness wrote Kai Kupferschmidt.

Dr. Osmond, the man who coined "psychedelic"
Dr. Osmond, the man who coined “psychedelic”

Historians of medicine and drugs have long held a view that psychoactive substances conform to cyclical patterns involving intense periods of enthusiasm, therapeutic optimism, critical appraisals, and finally limited use. The duration of this cycle has varied, but this historical model suggests psychedelics are due for a comeback tour. It was just a matter of time…

See the full article at Alternet.org
http://www.alternet.org/drugs/lsd-has-wondrous-uses-we-havent-even-begun-tap