When MAOIs are taken along with other antidepressants what condition can occur?

Rarely, an MAOI can cause dangerously high levels of serotonin, known as serotonin syndrome. It most often occurs when two medications that raise serotonin are combined. These include, for example, other antidepressants, certain pain or headache medications, and the herbal supplement St. John’s wort.

Can MAOIs and SSRIs be taken together?

The use of SSRIs and SNRIs should be avoided with an MAOI because of the risk of serious adverse effects and even death. The combination has a high risk of serotonin syndrome, and deaths have been reported when taken at therapeutic doses.

What medications should not be taken with MAOIs?

What drugs interact with MAOIs? MAO inhibitors should be avoided with other antidepressants such as paroxetine fluoxetine, amitriptyline, nortriptyline, bupropion; pain medications like methadone, tramadol, and meperidine; dextromethorphan, St. Johns Wort, cyclobenzaprine, and mirtazapine.

Why should MAOIs and SSRIs not be given concurrently?

It is generally considered dangerous to combine monoamine oxidase inhibitors and SSRIs because MAOIs inhibit serotonin metabolism and can result in circulating serotonin levels that are high enough to produce cardiotoxic and neurotoxic serotonin syndrome.

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What conditions are MAOIs used to treat?

Monoamine oxidase inhibitors (MAOIs) are a class of medication used to treat depression. They were introduced in the 1950s as the first drugs for depression.

Some side effects of MAOIs include:

  • fatigue.
  • muscle aches.
  • nervousness.
  • insomnia.
  • reduced libido.
  • erectile dysfunction (ED)
  • dizziness.
  • lightheadedness.

What is the difference between SSRI and MAOI?

Monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitors (SSRIs) are types of antidepressants used to treat depression. MAOIs are an older class of antidepressants that are not used as much because of drug and food interactions. MAOIs also are used to treat Parkinson’s disease.

Which antidepressants are MAOI?

The Food and Drug Administration (FDA) has approved these MAOIs to treat depression:

  • Isocarboxazid (Marplan)
  • Phenelzine (Nardil)
  • Selegiline (Emsam)
  • Tranylcypromine (Parnate)

Why are MAOIs not used as often?

They’re used less frequently than selective serotonin reuptake inhibitors (SSRIs) and other antidepressants because of necessary dietary precautions and risks of adverse reactions when mixed with certain drugs. Some common MAOIs include: Emsam (selegiline)

How long does it take MAOI to work?

Like other antidepressants, MAOIs can often take several weeks to start working. For example, it can take four weeks or longer before you begin to notice the full benefits of phenelzine, one of several commonly used monoamine oxidase inhibitors.

Do antihistamines affect antidepressants?

Some antihistamines can increase the depressant effects (such as sleepiness) of a sedative or tranquilizer. The sedating effect of some antihistamines combined with a sedating antidepressant could strongly affect your concentration level.

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What is the difference between SSRI and tricyclic antidepressants?

Tricyclic antidepressants usually have more of an effect on norepinephrine levels than on serotonin levels. SSRIs also cause more serotonin to be available for neurons to use, by selectively inhibiting serotonin transporters.

How effective are MAOIs?

Despite their potential side effects, the older MAOIs (phenelzine, tranylcypromine, isocarboxazid, and selegiline) have all been proven effective in depression; some studies have found them more effective than tricyclic antidepressants (TCAs) or selective serotonin reuptake inhibitors (SSRIs).

What are the side effects of SSRIs?

Common side effects of SSRIs can include:

  • feeling agitated, shaky or anxious.
  • feeling or being sick.
  • indigestion.
  • diarrhoea or constipation.
  • loss of appetite and weight loss.
  • dizziness.
  • blurred vision.
  • dry mouth.

What foods should be avoided with MAOIs?

Certain foods and drinks can cause dangerous reactions if they’re taken with an MAOI.

Some restricted foods may include:

  • Aged cheeses.
  • Yogurt.
  • Cured meats and certain other meat products.
  • Fermented sausages such as pepperoni, salami, and bologna.
  • Beef or chicken liver.
  • Anchovies.
  • Caviar.
  • Herring.


Which of the following foods should a patient on MAOIs avoid?

Smoked or processed meats, such as hot dogs, bologna, bacon, corned beef or smoked fish. Pickled or fermented foods, such as sauerkraut, kimchi, caviar, tofu or pickles. Sauces, such as soy sauce, shrimp sauce, fish sauce, miso and teriyaki sauce. Soybeans and soybean products.

Is Nardil an antidepressant?

Nardil is a prescription medicine used to treat the symptoms of Depression. Nardil may be used alone or with other medications. Nardil belongs to a class of drugs called Antidepressants, MAO Inhibitors.

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