What was notable about Prozac when it was introduced as a drug?

What was Prozac originally used for?

Prozac, trade name of fluoxetine hydrochloride, first of the class of antidepressant medications called selective serotonin reuptake inhibitors (SSRIs). It was introduced by Eli Lilly pharmaceutical company as a treatment for clinical depression in 1986.

The drugs became so popular in large part because many patients benefited from the treatment and experienced significantly reduced depressive symptoms. Such patients needn’t question why their symptoms have improved or whether they should seek alternative forms of treatment.

Why is Prozac The drug of choice?

Prozac is selective serotonin reuptake inhibitor (SSRI). It works by blocking the absorption of the neurotransmitter serotonin in the brain. Regulating the amount of serotonin helps brain cells transmit messages to each other. This results in a better and more stable mood.

Fluoxetine was approved by the FDA in December of 1987 and was launched to the market in January 1988 under the trade name Prozac® (for an excellence review on the development of fluoxetine see Wong, Bymaster, & Engleman, 1995; Wong, Perry, & Bymaster, 2005).

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Is Prozac bad for your kidneys?

Fluoxetine (applies to Prozac) renal dysfunction

Minor Potential Hazard, Low plausibility. Fluoxetine is primarily metabolized by the liver. All but one metabolites are inactive, and they are excreted by the kidney. The clearance of norfluoxetine, the active metabolite, is not dependent on renal function.

Why is Prozac bad?

The “if depressed, then Prozac” model puts millions of people needlessly at risk of serious side effects. The most dangerous of these is an “overstimulation reaction” that has been linked to compulsive thoughts of suicide and violence.

What is the #1 antidepressant?

Zoloft is the most commonly prescribed antidepressant; nearly 17% of those survey in the 2017 antidepressant use study reported that they had taken this medication. 1

Does Prozac permanently change brain?

Selective serotonin reuptake inhibitors (SSRI) such as Prozac are regularly used to treat severe anxiety and depression. They work by immediately increasing the amount of serotonin in the brain and by causing long term changes in brain function.

Is Prozac a happy pill?

The original “happy pill” was fluoxetine, more commonly known as Prozac. This medication, approved for use in 1987, was the first drug of its kind to be prescribed and marketed on a large scale. The use of this medication is very common, especially for the treatment of depression, but it is not without its risks.

What is the most common side effect of Prozac?

Common side effects include feeling sick (nausea), headaches and trouble sleeping. They are usually mild and go away after a couple of weeks. If you and your doctor decide to take you off fluoxetine, your doctor will probably recommend reducing your dose gradually to help prevent extra side effects.

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What are the long term side effects of fluoxetine?

To date, there are no known problems associated with long term use of fluoxetine. It is a safe and effective medication when used as directed.

Can Prozac cause weight gain?

Experts say that for up to 25% of people, most antidepressant medications — including the popular SSRI (selective serotonin reuptake inhibitor) drugs like Lexapro, Paxil, Prozac, and Zoloft — can cause a weight gain of 10 pounds or more.

What does Prozac do to your brain?

As an SSRI, Prozac works by preventing the brain from reabsorbing naturally occurring serotonin. Serotonin is involved in mood regulation. In this way, Prozac helps the brain to maintain enough serotonin so that you have a feeling of well-being, resulting from improved communication between brain cells.

When was Prozac banned?

Its use among children was banned in June 2003 after new information about its safety became available to the MHRA.

What is Prozac comparable to?

Prozac and Zoloft are powerful prescription medications used to treat depression and other issues. They’re both brand-name drugs. The generic version of Prozac is fluoxetine, while the generic version of Zoloft is sertraline hydrochloride. Both drugs are selective serotonin reuptake inhibitors (SSRIs).

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