Valproic acid is commonly used in the treatment of both epilepsy and bipolar disorder. It induces transient sedation, dizziness, somnolence, reversible thrombocytopenia, and serious adverse reactions like hepatotoxicity, encephalopathy, endocrine disturbances and pancreatitis.
Does valproic acid make you sleepy?
you should know that valproic acid can cause extreme drowsiness that may cause you to eat or drink less than you normally would, especially if you are elderly. Tell your doctor if you are not able to eat or drink as you normally do.
Is valproic acid a sedative?
Valproic acid may reduce sedative, opioid and antipsychotic requirements. Valproic acid appears well-tolerated in ICU patients with agitation and/or delirium.
What does valproic acid make you feel like?
Valproic acid may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you notice any of these side effects, tell your doctor right away.
Does Depakote make you sleepy?
A: Common side effects experienced with Depakote include drowsiness, nausea, abdominal pain, diarrhea, vomiting, low platelet count, tremors, tiredness, and hair loss. The side effects may be mild to moderate, but they may also be signs of a more serious condition.
Who should not take valproic acid?
You should not use valproic acid if you are allergic to it, or if you have: liver disease; a urea cycle disorder; or. a genetic mitochondrial (MYE-toe-KON-dree-al) disorder such as Alpers’ disease or Alpers-Huttenlocher syndrome, especially in a child younger than 2 years old.
Can valproic acid damage brain?
Hyperammonemia is known to cause neuronal injury, and can result from valproic acid exposure. Prompt reduction of elevated ammonia levels may prevent permanent neurological injury. We report a case of fatal hyperammonemic brain injury in a woman exposed to valproic acid.
What are the side effects of valproic acid?
Common side effects
- stomach pain, feeling or being sick (nausea or vomiting)
- dry or sore mouth, or swollen gums.
- shakes (tremors) in a part of your body, or unusual eye movements.
- feeling tired or sleepy.
- weight gain.
- thinning hair, or changes to the colour or texture of your hair.
How is sedation phenobarbital?
Phenobarbital is a safe drug and the patient are comfortable sedated. There is no significant decrease in blood pressure after bolus application. There is no prolongation of sedation in contrast to continuous given midazolam. All patients waked up comfortable.
What kind of drugs are benzodiazepines?
Benzodiazepines (sometimes called “benzos”) work to calm or sedate a person, by raising the level of the inhibitory neurotransmitter GABA in the brain. Common benzodiazepines include diazepam (Valium), alprazolam (Xanax), and clonazepam (Klonopin), among others.
How long does valproic acid stay in your system?
In healthy adults, it takes 2-3 days, on average, for most of the valproic acid to be gone from the body.
How long does it take for valproic acid to work?
When will valproic acid start working? When used as a mood stabilizer to control a manic episode, valproic acid needs to be taken for 1 to 2 weeks before you notice an improvement in your symptoms. You may notice an improvement earlier if valproic acid is combined with other medications.
Why does valproic acid cause weight gain?
Alterations in energy intake or expenditure can result from, or be associated with, changes in biological mechanisms, including hormone levels. In vitro studies suggest that VPA initiates pancreatic insulin secretion that might increase appetite and energy storage and result in weight gain (Luef, et al., 2003).
What are signs of Depakote toxicity?
CNS findings in cases of VPA overdose may include the following:
- Worsened seizure control.
Does Depakote help anxiety?
Valproic Acid (Depakote)
Valproic acid is an epilepsy medication that is now used for the treatment of panic attacks as well as other psychiatric problems. May work better by adding it to a primary medication that is not completely effective. Possible Disadvantages.
What can you not take with Depakote?
Some products that may interact with this drug include: certain antidepressants (e.g., amitriptyline, nortriptyline, phenelzine), certain antibiotics (carbapenems such as doripenem, imipenem), irinotecan, mefloquine, orlistat, other medications for seizure (e.g., ethosuximide, lamotrigine, phenytoin, rufinamide, …