Results: Of the patients receiving olanzapine, 66.6% had a weight gain of 1–5 kg over a period of 4 weeks. The weight gain was not related to the dose of the drug or BMI.
How much weight do you gain on olanzapine?
The mean weight gain was 7.9 kg during the 12-week period of olanzapine treatment, with patients gaining 2.4, 4.0, and 1.5 kg at the first, second, and third 4-week period, respectively. Female patients were more likely to gain weight (P < 0.001), with 9.19-kg mean weight gain during the study period compared with 5.90 …
Can olanzapine weight gain be reversed?
Results. The weight gain improved after switching the medication, from 80.3 to 75.0 kg, a weight loss of 6.6%, and there was no significant worsening of psychological symptoms or other adverse effects.
Has anyone lost weight on olanzapine?
Results: Patients incurred an average weight loss of 2.7 +/- 0.7 kg (p = 0.001) after switching patients from olanzapine SOT to olanzapine ODT at 12 months. Peak weight loss was observed at 6 months; however, significant weight loss was achieved as early as 3 months.
Does 2.5mg olanzapine cause weight gain?
Clinically significant weight gain was observed across all baseline Body Mass Index (BMI) categories. Following short-term treatment (median duration 47 days), weight gain ≥7% of baseline body weight was very common (22.2 %); ≥15 % was common (4.2 %); and ≥25 % was uncommon (0.8 %).
How does Olanzapine make you feel?
It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic. Olanzapine rebalances dopamine and serotonin to improve thinking, mood, and behavior. Symptoms of schizophrenia include: Hallucinations — imagined voices or images that seem real.
Does olanzapine work right away?
Response and effectiveness. Peak blood levels are reached within six hours of taking a single dose of oral olanzapine. Effects are long lasting, so olanzapine should be dosed once a day; however, it may take several weeks of continued dosing before a reduction in symptoms is seen.
Why is there weight gain with olanzapine?
Most research has focused on clozapine and olanzapine, the two medications identified to cause the highest weight gain. The high likelihood of weight gain with these medications has been linked to their actions at serotonin 5-HT2A and 5-HT2C, dopamine D2 and D3, histamine H1 and muscarinic M3 receptors.
Does everyone gain weight on olanzapine?
The results of the study revealed that there is a significant gain in weight with olanzapine, which is related to age ≥40 years and sex; women ≥40 years of age are more prone to gain weight in comparison with those <40 years and men of any age group. The weight gain is not related to the dose of olanzapine and BMI.
Does olanzapine cause belly fat?
Olanzapine is the one of first line antipsychotic drug for schizophrenia and other serious mental illness. However, it is associated with troublesome metabolic side-effects, particularly body weight gain and obesity.
Does olanzapine affect your metabolism?
Indeed, reduced body temperature after olanzapine treatment may generate many of the known side effects of this antipsychotic drug. The authors’ new findings also demonstrate that olanzapine alters peripheral glucose metabolism, which may contribute to impaired insulin sensitivity.
How do you avoid weight gain on antipsychotics?
The main approaches to managing weight with antipsychotics are: Ensure that the risk of weight gain, and other side effects, are considered when choosing an antipsychotic. Wherever possible use drugs with a lower risk of weight gain. Monitor weight and Body Mass Index (BMI) during antipsychotic treatment.
Is olanzapine used for anxiety?
Atypical antipsychotics such as quetiapine, aripiprazole, olanzapine, and risperidone have been shown to be helpful in addressing a range of anxiety and depressive symptoms in individuals with schizophrenia and schizoaffective disorders, and have since been used in the treatment of a range of mood and anxiety disorders …
Is 2.5 mg of olanzapine a lot?
Your doctor may adjust your dose as needed. However the dose is usually not more than 18 mg of olanzapine and 75 mg of fluoxetine per day. Children 10 to 17 years of age—At first, 2.5 milligrams (mg) of olanzapine and 20 mg of fluoxetine once a day in the evening. Your doctor may adjust your dose as needed.
Who should not take olanzapine?
low levels of white blood cells. low levels of a type of white blood cell called neutrophils. suicidal thoughts. a type of movement disorder called parkinsonism.
Is olanzapine safe for long term use?
High doses or long-term use of olanzapine can cause a serious movement disorder that may not be reversible. The longer you use olanzapine, the more likely you are to develop this disorder, especially if you are a woman or an older adult.