ZOLOFT is extensively metabolized by the liver. In patients with chronic mild liver impairment, sertraline clearance was reduced, resulting in increased AUC, Cmax and elimination half-life. The effects of sertraline in patients with moderate and severe hepatic impairment have not been studied.
Is sertraline metabolized in the liver?
Sertraline is metabolized at least in part by the liver, mainly via the cytochrome P450 system and PYP 2D6 and 2B6 which can cause drug-drug interactions.
How does sertraline metabolize?
The metabolism of sertraline is mainly catalyzed by CYP3A4 and CYP2B6, with some activity accounted for by CYP2C19 and CYP2D6. Since sertraline is extensively metabolized, excretion of unchanged drug in the urine is a minor route of elimination, with 12-14% of unchanged sertraline excreted in the feces.
How fast does sertraline metabolize?
Sertraline is eliminated from the body by other metabolic pathways to form a ketone and an alcohol, which are largely excreted renally as conjugates. The elimination half-life of sertraline ranges from 22-36 hours, and once-daily administration is therapeutically effective.
Can Zoloft cause kidney problems?
This drug may also decrease your kidney function, making your kidney disease worse. For people with liver problems: If you have liver problems or a history of liver disease, your body may not be able to process this drug as well.
Why is Zoloft bad for you?
Taking Zoloft may put you at risk for a rare, but possibly life-threatening condition called serotonin syndrome. This risk is higher if you are also taking other serotonin-related medications like triptans (a common migraine medication), tricyclic antidepressants, or the pain medication Ultram (tramadol).
How does zoloft make you feel at first?
Your doctor may start you on a low dose and gradually increase the dose over time. It’s common to experience headaches, nausea, and fatigue during your first week on Zoloft. These side effects often get better over the first week or two.
Is 50mg of Zoloft a lot?
Most studies suggest that the most effective dose of Zoloft is 50 mg per day. This dose is proven to be the most effective and tolerable dose for most patients.
Does sertraline affect your immune system?
SSRIs have been shown to alter several aspects of immune cell functioning. Not only the proliferation, but also cytokine secretion and viability of lymphocytes are affected when exposed to SSRIs. In addition to lymphocytes, cancer cells also seem to undergo changes when they are incubated with SSRIs , , .
Is 25mg of Zoloft enough for anxiety?
The standard dose of Zoloft for anxiety is 25 mg or 50 mg per day. According to the Food and Drug Administration (FDA), these are the standard doses of Zoloft for other disorders: Major depressive disorder: 50 mg daily. OCD: 50 mg per day for those older than 13 years of age.
Why should you not take sertraline on a night?
Many people who experience nausea and other side effects from sertraline opt to take it at night in order to limit these side effects. Since sertraline can interfere with sleep in a small percentage of users, many people also opt to take sertraline in the morning.
What foods should be avoided when taking Zoloft?
Tyramine-Rich Food Products:Interaction between sertraline and tyramine-rich foods like cheese, milk, beef, chicken liver, meat extract, avocados, bananas, canned figs, soy beans and excess chocolate can result in a sudden and dangerous increase in blood pressure.
How long till Zoloft is out of your system?
Zoloft has a half-life of about one day. That means that for every day that passes without taking the medication, the level in the blood falls by 50 percent. After one day, the level is reduced to 50 percent of the original level, after two days to 25 percent, after three days to 12.5 percent, and so on.
What are the long term side effects of Zoloft?
To date, there are no known problems associated with long term use of sertraline. It is a safe and effective medication when used as directed.
Can Zoloft raise blood pressure?
The only antidepressants that don’t cause high blood pressure as a side effect are selective-serotonin reuptake inhibitors (SSRIs) such as sertraline, citalopram, fluoxetine, and paroxetine. So, make sure the doctor prescribing your mental health medications knows if you have hypertension.
Can sertraline make you feel hyperactive?
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.