How is trazodone metabolized?

Trazodone is extensively metabolized by the liver, mainly via the cytochrome P450 system (CYP3A4), and hepatotoxicity may be mediated by toxic intermediates of its metabolism. Trazodone is susceptible to multiple drug-drug interactions.

Is trazodone processed through the kidneys?

Trazodone undergoes metabolism in the liver. The metabolites, at least one of which is pharmacologically active, are excreted by the kidney.

Is Trazadone bad for the liver?

Trazodone may cause alteration of liver enzyme levels at normal doses, but elevations are usually modest and usually do not require dose modification or discontinuation. Rare instances of ALF and death from trazodone have been described.

Where is trazodone absorbed?

Trazodone is rapidly absorbed in the gastrointestinal tract after oral administration, with a bioavailability ranging from 63-91% 9 and an AUC0−t of 18193.0 ng·h/mL.

What are the negative side effects of trazodone?

Trazodone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache.
  • nausea.
  • vomiting.
  • bad taste in mouth.
  • diarrhea.
  • constipation.
  • changes in appetite or weight.
  • weakness or tiredness.
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Does Trazodone go through the liver?

Trazodone is extensively metabolized by the liver, mainly via the cytochrome P450 system (CYP3A4), and hepatotoxicity may be mediated by toxic intermediates of its metabolism. Trazodone is susceptible to multiple drug-drug interactions.

Is sertraline bad for your kidneys?

For people with kidney problems: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of this drug in your body and cause more side effects. This drug may also decrease your kidney function, making your kidney disease worse.

Which painkiller is easiest on the liver?

Acetaminophen is broken down by the liver and can form byproducts that are toxic to the liver, so this warning is not completely without merit. But take it from a hepatologist, acetaminophen is the best option for pain relief for people with liver disease.

What can I drink to flush my liver?

How Do You Flush Out Your Liver?

  1. Flush out with plenty of water intake: Water is the best flushing agent. …
  2. Get regular exercise: Exercise helps to burn extra calories that reduce your risk of diabetes, excess weight, high blood pressure, and high blood fat.

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What medications are hard on the liver?

The 10 Worst Medications for Your Liver

  • 1) Acetaminophen (Tylenol) …
  • 2) Amoxicillin/clavulanate (Augmentin) …
  • 3) Diclofenac (Voltaren, Cambia) …
  • 4) Amiodarone (Cordarone, Pacerone) …
  • 5) Allopurinol (Zyloprim) …
  • 6) Anti-seizure medications. …
  • 7) Isoniazid. …
  • 8) Azathioprine (Imuran)

Does Trazodone make you gain weight?

Will I gain or lose weight? Trazodone can make you feel more or less hungry than usual, so you may lose or gain weight when you start taking it. If you start to have problems with your weight while taking trazodone, talk to your doctor or pharmacist.

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How long do you sleep on trazodone?

The 3 to 6 hour half-life of trazodone makes it most suitable for treating sleep onset insomnia or maintenance insomnia. Trazodone as a sleep aid has several core benefits: Scientifically proven to effectively treat both primary insomnia and secondary insomnia. Trazodone can be used to treat sleep issues at low doses.

How quickly does trazodone absorb?

Trazodone is rapidly absorbed, with peak plasma concentrations occurring 1 to 2 hours after oral doses. Like TCAs, it is highly (85% to 95%) protein bound. Trazodone has a relatively short half-life, approximately 5 to 9 hours.

What should you not take with Trazodone?

Drugs you should not use with trazodone

Examples of these drugs include: Monoamine oxidase inhibitors (MAOIs), such as isocarboxazid, phenelzine, tranylcypromine, or selegiline. You shouldn’t take trazodone with MAOIs or within 14 days of taking them. Taking these drugs together raises your risk for serotonin syndrome.

Can trazodone affect memory?

Trazodone produced small but significant impairments of short-term memory, verbal learning, equilibrium, and arm muscle endurance across time points.

Does Trazodone work right away for sleep?

A handful of studies have shown that trazodone may improve sleep during the first two weeks of treatment. But the drug hasn’t been well-studied for longer than six weeks for people whose primary problem is insomnia.

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