Around 20% of people on Paxil, Zoloft, Celexa, or Lexapro will experience some degree of withdrawal following termination of treatment, lasting anywhere from one to three weeks. 4 For those who have been on SSRIs for many years, the symptoms may persist for longer.
How long does SSRI withdrawal last?
Those who took antidepressants in higher doses for a longer time have more intense symptoms. Withdrawal symptoms typically persist for up to three weeks. The symptoms gradually fade during this time. Most people who quit taking their antidepressants stop having symptoms after three weeks.
Do SSRIs have permanent effects?
What are the long-term effects of common antidepressant medications, such as SSRIs or SNRIs? Do they cause permanent changes? There is no evidence, and little reason to believe, that the commonly prescribed antidepressant medications cause any permanent changes to the brain or have any persistent side effects.
Is it hard to get off antidepressants?
Withdrawal can be unpleasant. Slowly tapering off your antidepressant can help you avoid these symptoms. By gradually reducing the dose of the drug over a period of four or more weeks, you’ll give your body time to adapt before you switch to a new drug.
What is the easiest SSRI to get off of?
Fluoxetine, which has the longest half-life of the SSRIs (see Table 1), appears to produce the fewest withdrawal symptoms, while paroxetine, which has the shortest half-life, produces the most pronounced discontinuation effects.
Do SSRIs permanently change your brain?
Selective serotonin reuptake inhibitors (SSRI) such as Prozac are regularly used to treat severe anxiety and depression. They work by immediately increasing the amount of serotonin in the brain and by causing long term changes in brain function.
What does SSRI withdrawal feel like?
The most common symptoms of SSRI discontinuation syndrome are described as either being flu-like, or feeling like a sudden return of anxiety or depression.
Do antidepressants shorten your lifespan?
The analysis found that in the general population, those taking antidepressants had a 33 percent higher risk of dying prematurely than people who were not taking the drugs. Additionally, antidepressant users were 14 percent more likely to have an adverse cardiovascular event, such as a stroke or a heart attack.
Can SSRIs damage your brain?
“Perhaps we should be a bit more cautious than we are at the moment, about who we use antidepressants for. We need more research.” He notes, however, that SSRI’s have been in use for some 25 years and there is no evidence of brain damage or a negative impact on intellectual capacity.
Do antidepressants ruin your brain?
We know that antipsychotics shrink the brain in a dose-dependent manner (4) and benzodiazepines, antidepressants and ADHD drugs also seem to cause permanent brain damage (5).
What is the hardest antidepressant to come off of?
- citalopram) (Celexa)
- escitalopram (Lexapro)
- paroxetine (Paxil)
- sertraline (Zoloft)
Is antidepressant weight gain permanent?
Researchers at King’s College London found that all twelve of the leading antidepressants — including fluoxetine (Prozac), sertraline (Zoloft), and escitalopram (Lexapro) — increased risk for weight gain for up to six years after starting treatment.
How do I wean myself off antidepressants?
If you’re thinking about stopping antidepressants, you should go step-by-step, and consider the following:
- Take your time. …
- Make a plan. …
- Consider psychotherapy. …
- Stay active. …
- Seek support. …
- Complete the taper. …
- Image: AlinaTraut/Getty Images.
Which SSRI is most effective?
Zoloft (sertraline): Zoloft is highly effective, although some people find it’s more likely than other SSRIs to cause diarrhea. Zoloft is the most commonly prescribed antidepressant; nearly 17% of those survey in the 2017 antidepressant use study reported that they had taken this medication. 1
What is the safest SSRI?
Citalopram and escitalopram have been considered the safest among the SSRIs with respect to potential for liver injury .
Which SSRI is best for anxiety?
The antidepressants most widely prescribed for anxiety are SSRIs such as Prozac, Zoloft, Paxil, Lexapro, and Celexa.