Results: Patients incurred an average weight loss of 2.7 +/- 0.7 kg (p = 0.001) after switching patients from olanzapine SOT to olanzapine ODT at 12 months. Peak weight loss was observed at 6 months; however, significant weight loss was achieved as early as 3 months.
Does everyone gain weight on olanzapine?
The results of the study revealed that there is a significant gain in weight with olanzapine, which is related to age ≥40 years and sex; women ≥40 years of age are more prone to gain weight in comparison with those <40 years and men of any age group. The weight gain is not related to the dose of olanzapine and BMI.
Can you lose weight on antipsychotics?
Various interventions can help and a psychiatrist will be able to offer advice on these. Many people taking antipsychotics can lose some weight with simple changes to their diet and lifestyle. Losing even a small amount of weight can have important health benefits.
Does olanzapine affect your metabolism?
Indeed, reduced body temperature after olanzapine treatment may generate many of the known side effects of this antipsychotic drug. The authors’ new findings also demonstrate that olanzapine alters peripheral glucose metabolism, which may contribute to impaired insulin sensitivity.
Does olanzapine prevent weight gain?
Similarly, olanzapine which ranks high in terms of efficacy carries higher risk of weight gain than most other antipsychotics. Since the risk of weight gain appears to be highest in the first year of treatment, careful monitoring and early intervention are the first step in managing AIWG.
How much weight will I gain on olanzapine?
The mean weight gain was 7.9 kg during the 12-week period of olanzapine treatment, with patients gaining 2.4, 4.0, and 1.5 kg at the first, second, and third 4-week period, respectively. Female patients were more likely to gain weight (P < 0.001), with 9.19-kg mean weight gain during the study period compared with 5.90 …
How does Olanzapine make you feel?
It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic. Olanzapine rebalances dopamine and serotonin to improve thinking, mood, and behavior. Symptoms of schizophrenia include: Hallucinations — imagined voices or images that seem real.
What antidepressant helps you lose weight?
Bupropion is an antidepressant that may lead to weight loss in some people.
How do you reverse weight gain from antipsychotics?
Jan. 8, 2008 — The diabetes drug metformin — especially with a diet/exercise regimen — largely reverses the weight-gain side effect of antipsychotic drugs.
Why do you gain weight on antipsychotics?
Why Do Antipsychotics Make You Gain Weight? Antipsychotic drugs can make you hungrier, so you might eat more. That’s because they change the way your brain and hormones work together to control your appetite. You might crave sweets or fatty foods.
Do antipsychotics ruin your metabolism?
Furthermore, antipsychotics—particularly the second generation, or “atypical” antipsychotics—can induce serious metabolic side effects, such as obesity, dyslipidemia and type 2 diabetes, illnesses which themselves have been linked to impairments in cognition.
Will 2.5 mg of olanzapine cause weight gain?
Clinically significant weight gain was observed across all baseline Body Mass Index (BMI) categories. Following short-term treatment (median duration 47 days), weight gain ≥7% of baseline body weight was very common (22.2 %); ≥15 % was common (4.2 %); and ≥25 % was uncommon (0.8 %).
What are the side effects of olanzapine?
Olanzapine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- dizziness, feeling unsteady, or having trouble keeping your balance.
- unusual behavior.
- difficulty falling asleep or staying asleep.
- difficulty walking.
Does olanzapine cause belly fat?
Olanzapine is the one of first line antipsychotic drug for schizophrenia and other serious mental illness. However, it is associated with troublesome metabolic side-effects, particularly body weight gain and obesity.
Is olanzapine a good drug?
Olanzapine has an average rating of 6.0 out of 10 from a total of 761 ratings on Drugs.com. 47% of users who reviewed this medication reported a positive effect, while 31% reported a negative effect.
Does 5mg of olanzapine cause weight gain?
In the short term (<6 weeks), men’s average weight increased by 3.4 kg and women’s average weight increased by 2.3 kg on olanzapine. In terms of dose, women receiving a high dose (>5 mg) gained an average 3.2 kg in the short term compared with 1.9 kg on a low dose (≤5 mg). Weight gain slowed after the first 6 weeks.