Prozac, trade name of fluoxetine hydrochloride, first of the class of antidepressant medications called selective serotonin reuptake inhibitors (SSRIs). It was introduced by Eli Lilly pharmaceutical company as a treatment for clinical depression in 1986.
When was Prozac first used?
Fluoxetine was approved by the FDA in December of 1987 and was launched to the market in January 1988 under the trade name Prozac® (for an excellence review on the development of fluoxetine see Wong, Bymaster, & Engleman, 1995; Wong, Perry, & Bymaster, 2005).
Why was fluoxetine invented?
Three pharmaceutical researchers working at Eli Lilly in the 1980s changed the treatment of depression with their invention of Prozac. In 1988 the pharmaceutical firm Eli Lilly and Company introduced Prozac (fluoxetine), a new type of antidepressant that was safer and more effective than those of previous eras.
Why was Prozac so popular?
The drugs became so popular in large part because many patients benefited from the treatment and experienced significantly reduced depressive symptoms. Such patients needn’t question why their symptoms have improved or whether they should seek alternative forms of treatment.
What is the science behind Prozac?
The molecule is a potent triple reuptake inhibitor (TRI), blocking the breakdown of serotonin, noradrenaline and dopamine. While Prozac only alters serotonin, other successful anti-depressants, such as venlafaxine, block the reuptake of serotonin and noradrenaline.
Is Prozac a happy pill?
The original “happy pill” was fluoxetine, more commonly known as Prozac. This medication, approved for use in 1987, was the first drug of its kind to be prescribed and marketed on a large scale. The use of this medication is very common, especially for the treatment of depression, but it is not without its risks.
Why was Prozac banned?
Europe’s drugs watchdog has banned Prozac and other modern antidepressants for under-18s because of safety fears, putting it on a collision course with Britain’s drugs regulator.
Does fluoxetine cause depression?
Fluoxetine may cause some teenagers and young adults to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed.
Why is fluoxetine the drug of choice for depression?
Prozac is selective serotonin reuptake inhibitor (SSRI). It works by blocking the absorption of the neurotransmitter serotonin in the brain. Regulating the amount of serotonin helps brain cells transmit messages to each other. This results in a better and more stable mood.
Can Prozac cause weight gain?
Experts say that for up to 25% of people, most antidepressant medications — including the popular SSRI (selective serotonin reuptake inhibitor) drugs like Lexapro, Paxil, Prozac, and Zoloft — can cause a weight gain of 10 pounds or more.
What is the #1 antidepressant?
Zoloft is the most commonly prescribed antidepressant; nearly 17% of those survey in the 2017 antidepressant use study reported that they had taken this medication. 1
What is the most energizing antidepressant?
Prozac (fluoxetine) and Wellbutrin (bupropion) are examples of “energizing” antidepressants; whereas Paxil (paroxetine) and Celexa (citalopram) tend to be more sedating.
What is Prozac comparable to?
Prozac and Zoloft are powerful prescription medications used to treat depression and other issues. They’re both brand-name drugs. The generic version of Prozac is fluoxetine, while the generic version of Zoloft is sertraline hydrochloride. Both drugs are selective serotonin reuptake inhibitors (SSRIs).
What are the long term effects of Prozac?
Clinical studies have shown that there are many side effects upon chronic administration of SSRIs, like sexual dysfunction,9 suppression of rapid eye movement sleep,10 nausea,11, 12 decreased appetite13 and deterioration of symptoms (for example, aggression),14, 15 indicating that optimization of chronic treatment of …
Does Prozac rewire your brain?
Castrén’s study suggests Prozac returns regions of the brain to an immature state in which neurons make or break more connections with one another than is typical of the adult brain. In other words, Prozac increases brain plasticity.
Does Prozac alter your brain chemistry?
Selective serotonin reuptake inhibitors (SSRI) such as Prozac are regularly used to treat severe anxiety and depression. They work by immediately increasing the amount of serotonin in the brain and by causing long term changes in brain function.