Hepatotoxicity. Liver test abnormalities have been reported to occur in up to 1% of patients on sertraline, but elevations are usually modest and infrequently require dose modification or discontinuation.
Can SSRI cause elevated liver enzymes?
Results. Although data on antidepressant-induced liver injury are scarce, 0.5%−3% of patients treated with antidepressants may develop asymptomatic mild elevation of serum aminotransferase levels. All antidepressants can induce hepatotoxicity, especially in elderly patients and those with polypharmacy.
Can sertraline raise Alt?
Data from the premarketing evaluation of sertraline hydrochloride suggest that the rate of asymptomatic elevations in serum transaminases (AST and ALT) secondary to sertraline use is 0.8%, with most cases occurring within the first 9 weeks of drug initiation.
What medications can cause liver enzymes to be elevated?
Examples of drugs that more commonly cause elevations of liver enzymes in the blood include the statins (used in treating high blood cholesterol levels) some antibiotics, some antidepressants (used in treating depression), and some medications used for treating diabetes, tacrine (Cognex), aspirin, and quinidine ( …
Are antidepressants hard on your liver?
Some antidepressants can damage your liver over time, including monoamine oxidase (MAO) inhibitors, tricyclic or tetracyclic antidepressants, bupropion, duloxetine and agomelatine. Antidepressant drugs with a lower risk of liver damage include citalopram, escitalopram, paroxetine and fluvoxamine.
Is Zoloft hard on the liver?
Rare instances of acute liver failure have been attributed to sertraline therapy. Rechallenge usually results in recurrence of liver injury and should be avoided. Persons with intolerance to sertraline may have similar reactions to other SSRIs and careful monitoring is warranted if other such agents are used.
Is Prozac hard on the liver?
Introduction. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) widely used as an antidepressant. Fluoxetine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
Which antidepressant is easiest on the liver?
The antidepressants that seem to have the least potential for hepatotoxicity are citalopram, escitalopram, paroxetine, and fluvoxamine.
When should I worry about Alt?
Since high levels of ALT indicate liver damage or disease, it’s important to consult your physician if you have elevated ALT.
What happens if you drink alcohol with sertraline?
Mixing Zoloft with alcohol can exacerbate the symptoms of an upset stomach, possibly resulting in vomiting. Alcohol is a central nervous system depressant that by itself can cause depression. The consumption of alcohol can also worsen the symptoms of depression and make Zoloft less effective in treating these symptoms.
How serious is elevated liver enzymes?
In most cases, liver enzyme levels are only mildly and temporarily elevated. Most of the time, elevated liver enzymes don’t signal a chronic, serious liver problem.
How high is too high for liver enzymes?
Typically the range for normal AST is reported between 10 to 40 units per liter and ALT between 7 to 56 units per liter. Mild elevations are generally considered to be 2-3 times higher than the normal range. In some conditions, these enzymes can be severely elevated, in the 1000s range.
How long does it take for elevated liver enzymes to return to normal?
With acute Hepatitis, AST levels usually stay high for about 1-2 months but can take as long as 3-6 months to return to normal.
What are signs of unhealthy liver?
If signs and symptoms of liver disease do occur, the may include:
- Skin and eyes that appear yellowish (jaundice)
- Abdominal pain and swelling.
- Swelling in the legs and ankles.
- Itchy skin.
- Dark urine color.
- Pale stool color.
- Chronic fatigue.
- Nausea or vomiting.
What can I drink to flush my liver?
How Do You Flush Out Your Liver?
- Flush out with plenty of water intake: Water is the best flushing agent. …
- Get regular exercise: Exercise helps to burn extra calories that reduce your risk of diabetes, excess weight, high blood pressure, and high blood fat.
What medications are hard on the liver?
The 10 Worst Medications for Your Liver
- 1) Acetaminophen (Tylenol) …
- 2) Amoxicillin/clavulanate (Augmentin) …
- 3) Diclofenac (Voltaren, Cambia) …
- 4) Amiodarone (Cordarone, Pacerone) …
- 5) Allopurinol (Zyloprim) …
- 6) Anti-seizure medications. …
- 7) Isoniazid. …
- Azathioprine (Imuran)